We investigate how organisms respond to rapid environmental change. We are especially interested in how variable and extreme temperatures affect physiology across life stages, including early development and reproduction, since responses during these life stages can result in dramatic, transgenerational effects. Our work integrates thermal physiology, metabolism, and endocrinology to better predict the impacts of climate change and other anthropogenic stressors on animals. We study diverse taxa (reptiles, insects, and birds) and make use of start-of-the-art techniques from the field to the benchtop.